Drug class
Blood thinners (warfarin, direct-acting anticoagulants) and cannabis
Both CBD and THC can slow down the CYP2C9 and CYP3A4 liver enzymes that clear these drugs, so blood levels and INR can climb.
High risk
Why it happens
Both CBD and THC can slow down the CYP2C9 and CYP3A4 liver enzymes that clear these drugs, so blood levels and INR can climb.
What it means for you
Your bleeding risk can rise even though nobody changed your warfarin dose. INR readings may drift away from where they were.
What Tiffany advises
Tell your prescriber before you start cannabis. If you take warfarin, Tiffany suggests planning for more frequent INR checks during the first month.
Common examples
Generic names first, then brands.
- warfarin
- apixaban
- rivaroxaban
- dabigatran
Body systems involved
- Bleeding
- Heart and blood pressure
Take it further
Check this with my other meds
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